Table 3: Respiratory Parameters and Secondary Respiratory Health Outcomes.
Mean (standard deviation) of cumulative inspired oxygen exposure (FiO2AUC), cumulative mean airway pressure (MAPAUC), intermittent hypoxemia events per day, and mean oxygen saturation (SpO2) at Days 1–3, 1–7, and 1–28 of postnatal age. Relative Risk (95% Confidence Intervals) and p-values reported for variable’s association with parental reported respiratory outcomes (Yes or No) within the past 6 months of child’s two year follow-up visit by generalized estimating equations for Poisson regression models with clustering of twins or triplets within one mother. Adjusted for gestational age (weeks completed) and sex.
| In Last 6 Months, Wheezing or Whistling in the Chest >2 Days/Week | |||||||||||||||||||
| mean(SD) | Day 1–3 | RR (95% CI) | p | Adjusted RR (95% CI) | p | Day 1–7 | RR (95% CI) | p | Adjusted RR (95% CI) | p | Day 1–28 | RR (95% CI) | p | Adjusted RR (95% CI) | p | ||||
| Yes | No | Yes | No | Yes | No | ||||||||||||||
| FiO2AUC (% × day) | 96.0 (33.1) | 89.8 (23.2) | 1.01 (1.00,1.01) | .13 | 1.01 (1.00,1.01) | .18 | 202.5 (51.4) | 190.0 (38.0) | 1.00 (1.00,1.01) | .07 | 1.00 (1.00,1.01) | .20 | 955.1 (269.3) | 861.9 (246.6) | 1.001 (1.00,1.002) | .02 | 1.00 (1.00,1.00) | .30 | |
| MAPAUC (cm H2O × day) | 19.4 (5.4) | 18.6 (4.8) | 1.02 (0.98,1.07) | .30 | 1.02 (0.97,1.08) | .50 | 41.1 (16.4) | 40.1 (14.2) | 1.00 (0.99,1.02) | .70 | 1.00 (0.98,1.02) | .89 | 166.5 (74.8) | 161.0 (72.8) | 1.00 (1.00,1.00) | .69 | 1.00 (0.99,1.00) | .38 | |
| Intermittent Hypoxemia (per day) | 34 (35) | 23 (20) | 1.01 (1.004,1.01) | .0005 | 1.01 (1.004,1.02) | .0002 | 30 (25) | 23 (18) | 1.01 (1.003,1.02) | .01 | 1.01 (1.002,1.02) | .02 | 96 (57) | 87 (54) | 1.00 (0.98,1.01) | .34 | 1.00 (0.96,1.01) | .93 | |
| Mean SpO2 (%) | 93.8 (2.3) | 94.2 (2.4) | 0.95 (0.86,1.04) | .27 | 0.96 (0.87,1.07) | .46 | 93.8 (2.1) | 94.2 (2.1) | 0.93 (0.83,1.04) | .21 | 0.96 (0.85,1.08) | .49 | 92.6 (2.1) | 93.2 (2.5) | 0.93 (0.84,1.02) | .12 | 0.97 (0.88,1.07) | .58 | |
| In Last 6 Months, Visit to Doctor, Emergency Room, or Hospital Due To Wheezing/Breathing Problems | |||||||||||||||||||
| mean(SD) | Day 1–3 | RR (95% CI) | p | Adjusted RR (95% CI) | p | Day 1–7 | RR (95% CI) | p | Adjusted RR (95% CI) | p | Day 1–28 | RR (95% CI) | p | Adjusted RR (95% CI) | p | ||||
| Yes | No | Yes | No | Yes | No | ||||||||||||||
| FiO2AUC (% × day) | 93.8 (32.1) | 90.1 (21.5) | 1.00 (1.00,1.01) | .14 | 1.01 (1.00,1.01) | .05 | 195.2 (47.8) | 192.7 (38.6) | 1.00 (1.00,1.01) | .34 | 1.01 (1.00,1.01) | .07 | 867.6 (224.0) | 908.3 (279.2) | 1.00 (1.00,1.00) | .34 | 1.00 (1.00,1.00 | .11 | |
| MAPAUC (cm H2O × day) | 18.9 (5.6) | 18.7 (4.4) | 1.01 (0.97,1.04) | .66 | 1.01 (0.98,1.05) | .47 | 39.8 (16.3) | 40.8 (13.7) | 0.99 (0.99,1.01) | .70 | 1.00 (0.98,1.01) | .70 | 155.2 (66.8) | 168.5 (77.7) | 1.00 (1.00,1.00) | .28 | 1.00 (0.99,1.00) | .07 | |
| Intermittent Hypoxemia (per day) | 31 (33) | 23 (18) | 1.01 (1.002,1.01) | .002 | 1.01 (1.003,1.01) | .002 | 29 (24) | 23 (16) | 1.01 (1.003,1.02) | .003 | 1.01 (1.004,1.02) | .002 | 94 (55) | 87 (54) | 1.00 (0.98,1.00) | .64 | 1.00 (0.97,1.00) | .92 | |
| Mean SpO2 (%) | 93.8 (26) | 94.2 (2.2) | 0.97 (0.91,1.03) | .28 | 0.97 (0.93,1.03) | .39 | 94.0 (2.3) | 94.2 (2.0) | .099 (0.92,1.06) | .73 | 1.00 (0.93,1.07) | .96 | 93.0 (2.2) | 93.1 (2.5) | 0.98 (0.93,1.06) | .73 | 1.00 (0.94,1.06) | .93 | |
| In Last 6 Months, Had to Change Family Plans Due To Child’s Breathing Problems | |||||||||||||||||||
| mean(SD) | Day 1–3 | RR (95% CI) | p | Adjusted RR (95% CI) | p | Day 1–7 | RR (95% CI) | p | Adjusted RR (95% CI) | p | Day 1–28 | RR (95% CI) | p | Adjusted RR (95% CI) | p | ||||
| Yes | No | Yes | No | Yes | No | ||||||||||||||
| FiO2AUC (% × day) | 102.6 (37.1) | 89.6 (23.8) | 1.01 (1.003,1.02) | .008 | 1.01 (1.001,1.02) | .03 | 213.5 (54.1) | 190.0 (39.4) | 1.01 (1.003,1.01) | .003 | 1.01 (0.99,1.01) | .05 | 1009.7 (264.8) | 867.7 (249.5) | 1.001 (1.0004,1.002) | .008 | 1.00 (1.00,1.00) | .18 | |
| MAPAUC (cm H2O × day) | 20.1 (5.1) | 18.6 (4.9) | 1.05 (0.98,1.12) | .13 | 1.04 (0.96,1.13) | .32 | 43.0 (13.0) | 39.9 (15.2) | 1.01 (0.99,1.03) | .27 | 1.00 (0.98,1.03) | .78 | 186.0 (74.5) | 158.2 (72.4) | 1.00 (1.00,1.01) | .07 | 1.002 (1.00,1.01) | .66 | |
| Intermittent Hypoxemia (per day) | 31 (23) | 25 (27) | 1.01 (0.96,1.02) | .26 | 1.01 (0.98,1.02) | .13 | 33 (24) | 24 (20) | 1.02 (1.001,1.03) | .03 | 1.02 (1.002,1.03) | .02 | 97 (48) | 89 (56) | 1.00 (0.97,1.01) | .44 | 0.99 (0.93,1.01) | .79 | |
| Mean SpO2 (%) | 93.3 (2.0) | 94.2 (2.4) | 0.87 (0.77,0.99) | .04 | 0.88 (0.77,1.02) | .08 | 93.1 (2.1) | 94.3 (2.1) | 0.81 (0.69,0.94) | .007 | 0.84 (0.71,0.99) | .04 | 93.3 (2.3) | 91.9 (2.2) | 0.82 (0.72,0.94) | .004 | 0.85 (0.74,0.98) | .03 | |