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Hypothesized regulatory relationships between TGFβ, Tgif1, miR‐18a, and NeuroD during photoreceptor differentiation. Tgif1 functions downstream of Smad2 and Smad3 in the TGFβ signaling pathway (Lenkowski and Raymond, 2014). As a transcriptional corepressor, Tgif1 negatively regulates the expression of miR‐18a, and miR‐18a suppresses NeuroD protein levels to regulate the timing of photoreceptor differentiation.
