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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Ann Neurol. 2019 Jan 7;85(2):272–279. doi: 10.1002/ana.25399

Figure 2. Exploratory regional analyses depicting the interaction between the Framingham Heart Study cardiovascular disease risk score (FHS-CVD) and Aβ burden on tau burden.

Figure 2.

FreeSurfer-defined regions in which the interaction of FHS-CVD and Aβ correlated significantly with regional tau deposition. Regions were averaged across left and right hemispheres. In all regions shown, combined higher FHS-CVD and elevated Aβ was associated higher tau burden. Color bars indicate the t-statistic for the association, adjusting for age, sex, APOE ε4 status, and the time interval between baseline and the tau PET scan. Regions shown are p < 0.05 corrected for multiple comparisons (FWE).