Table 3.

Summary of linear regression models examining the interactive effect of the FHS-CVD components and Aβ burden on tau deposition in the inferior temporal cortex

	β estimate	Standard error	T value	P value	R2 of the model
ITC tau ~ Aβ*FHS-CVD Component + Aβ + FHS-CVD component + age + sex + APOE ε4 + time interval
Aβ*BMI	0.25	0.07	3.29	0.001	0.38
Aβ*SBP (mm Hg)	0.22	0.07	2.93	0.004	0.38
Aβ*HTN med	0.44	0.13	3.49	< 0.001	0.42
Aβ*Smoking status	0.81	0.31	2.60	0.01	0.35
Aβ*Diabetes	0.51	0.38	1.34	0.18	0.33

Linear regression models with FHS-CVD and Aβ burden as interactive predictors of tau deposition in the inferior temporal cortex, repeated for each vascular component of the FHS-CVD. Each row summarizes the results from a separate linear regression model. All continuous variables were z-transformed prior to model entry. T values represent the β estimate divided by the standard error. Abbreviations. BMI = body mass index; FHS-CVD = Framingham Heart Study cardiovascular disease risk score; HTN med = Treatment with antihypertensive medication; ITC = inferior temporal cortex; SBP = systolic blood pressure.