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. Author manuscript; available in PMC: 2020 Jan 23.
Published in final edited form as: Neurosci Lett. 2018 Oct 24;692:1–9. doi: 10.1016/j.neulet.2018.10.044

Figure 2. Impact of E.coli (1×106 CFU/0.1mL/kg) in the cerebellum of male and female neonates 8- and 24-hours following infection.

Figure 2.

(A) Relative gene expression of the proinflammatory cytokine IL-1β is not significantly different in males or females following neonatal infection at either time point. (B) Relative gene expression of the proinflammatory cytokine IL-6 is significantly increased in females 8 hours post-infection. (C) Relative gene expression of the proinflammatory cytokine TNF-α is not significantly different in males or females following neonatal infection at either time point. (D) Relative gene expression of a marker of microglial activation, CD11b, is significantly greater at 8 hours compared to 24 hours. (E) Relative gene expression of Iba-1 is lower in males compared to females at 8 hours, but not at 24 hours post-infection. (F) Relative gene expression of the trophic factor, BDNF, is significantly decreased in males following neonatal infection at 8 hours. Error bars represent ±SEM. †p < 0.05 represents the main effect of Time. βp < 0.05 represents a significant interaction of Sex and Time. ψp < 0.05 represents a significant interaction of Sex, Neonatal Treatment, and Time.