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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Food Chem Toxicol. 2018 Nov 29;124:112–127. doi: 10.1016/j.fct.2018.11.048

Figure 9. Scanning electron microscope (SEM) images of Caco-2/HT29-MX co-cultures exposed to zinc oxide nanoparticles (ZnO NP).

Figure 9.

Cells were exposed to low, medium and high doses of undigested and digested ZnO NP for 4 hours prior to fixing with 4% paraformaldehyde. SEM images were taken of Caco-2/HT29-MTX co-culture microvilli. A) undigested control, B) digested control, C) undigested low, D) digested low, E) undigested medium, F) digested medium, G) undigested high, H) digested high. Low, medium and high refer to the dose of ZnO nanoparticles, where low = 9.7 × 10−6 mg/mL, medium = 9.7 × 10−4 mg/mL, and high = 9.7 × 10−2 mg/mL. Digested refers to ZnO NP that were subjected to a simulated gastric and intestinal digestion.