Table 2.
Comparison of antibiotic resistance levels of the PmB heteroresistant mutant#
| Antibiotics | CNM3 | CNM3R4 | MS11 | CNG20 | FA19 |
|---|---|---|---|---|---|
| E test (μg/ml) | |||||
| Colistin | 53.3 ± 9.2 | 256** | 256 | 48 | 32 |
| Penicillin G | 0.22 ± 0.08 | 0.46 ± 0.10** | 0.25 | 0.064 | 0.012 |
| ceftriaxone | 0.002 ± 0.000 | 0.004 ± 0.001** | 0.002 | 0.002 | 0.002 |
| Cefotaxime | 0.01 ± 0.003 | 0.021 ± 0.004** | 0.012 | 0.004 | 0.002 |
| Azithromycin | 0.70 ± 011 | 0.85 ± 0.14 | 0.19 | 0.032 | 0.064 |
| Streptomycin | 7.8 ± 0.7 | 10.9 ± 2.0** | 1024 | 4 | 6 |
| Kanamycin | 10.9 ± 2.0 | 14.3 ± 2.1** | 8 | 8 | 4 |
| Chloramphenicol | 0.63 ± 0.13 | 0.81 ± 0.18* | 2 | 0.125 | 0.25 |
| Meropenem | 0.3 ± 0.1 | 0.3 ± 0.1 | 0.064 | 0.094 | 0.064 |
| Tetracycline | 0.19 ± 0.0 | 0.26 ± 0.1* | 0.5 | 0.25 | 0.094 |
| Levofloxacin | 0.008 ± 0.0 | 0.007 ± 0.0 | 0.004 | 0.002 | 0.003 |
#.
Data are presented as the mean ± standard deviation (N=3–8). The MIC values of antibiotics in bold are statistically different between CNM3 and 3R4 by student’s t test (**, p < 0.01; *, p < 0.05). A single data point is shown for each gonococcal strain as comparison.