Table 4. Univariate and multivariate analysis of selected prognostic factors for overall survival (OS).
| Characteristic | P value (univariate analysis) | P value (multivariate analysis) | Hazard ratio (95% CI) |
|---|---|---|---|
| Age | |||
| ≤40 years | 0.092 | 0.247 | 0.85–1.86 |
| >40 years | |||
| Signet ring histology | |||
| Yes | <0.001 | 0.003 | 1.27–3.06 |
| No | |||
| Mucinous histology | |||
| Yes | 0.047 | 0.430 | 0.75–1.96 |
| No | |||
| Tumor location | |||
| Upper 1/3 | |||
| Mid 1/3 | 0.125 | – | – |
| Lower 1/3 | |||
| T stage | |||
| T2 | |||
| T3 | 0.030 | 0.500 | 0.36–1.65 |
| T4 | |||
| N stage | |||
| N0 | 0.432 | – | – |
| N+ | |||
| Subtype of LARC | |||
| Favourable | |||
| Intermediate | 0.045 | 0.139 | 0.82–1.42 |
| Advanced | |||
| Baseline CEA | |||
| Raised | |||
| Not raised | 0.066 | 0.943 | 0.36–3.02 |
LARC, locally advanced rectal cancer; CEA, carcinoembryonic antigen.