Table 2. Treatment patterns and survival outcomes stage by stage*.
| Covariate | Gastric squamous cell carcinoma (n=689) | Gastric adenosquamous carcinoma (n=298) | Gastric adenocarcinoma (n=51,913) | Parametric P value** |
|---|---|---|---|---|
| Stage I, n | 84 | 38 | 11,178 | |
| Surgery, (Col %) | 35 (41.7) | 35 (92.1) | 8,465 (75.7) | <0.001 |
| Surgical margin positive, n (Col %) | 1 (1.2) | 4 (10.5) | 306 (2.7) | <0.001 |
| Chemotherapy, n (Col %) | 0.071 | |||
| Neoadjuvant chemotherapy | 8 (9.5) | 9 (23.7) | 1,065 (9.5) | |
| Adjuvant chemotherapy | 1 (1.2) | 4 (10.5) | 609 (5.4) | |
| Radiation therapy, n (Col %) | <0.001 | |||
| Before surgery | 11 (13.1) | 7 (18.4) | 901 (8.1) | |
| After surgery | 3 (3.6) | 6 (15.8) | 693 (6.2) | |
| Median survival, months | 16.1 | 14.0 | 32.2 | <0.001 |
| Stage II, n | 124 | 58 | 8,154 | |
| Surgery, n (Col %) | 74 (59.7) | 50 (86.2) | 6,112 (75.0) | <0.001 |
| Surgical Margin positive, n (Col %) | 3 (2.4) | 4 (6.9) | 545 (6.7) | <0.001 |
| Chemotherapy, n (Col %) | 0.004 | |||
| Neoadjuvant chemotherapy | 38 (30.6) | 16 (27.6) | 1,644 (20.2) | |
| Adjuvant chemotherapy | 4 (3.2) | 10 (17.2) | 1,465 (18.0) | |
| Radiation therapy, n (Col %) | <0.001 | |||
| Before surgery | 43 (34.7) | 16 (27.6) | 1,452 (17.8) | |
| After surgery | 8 (6.5) | 12 (20.7) | 1,662 (20.4) | |
| Median survival, months | 19.3 | 18.8 | 23.7 | 0.115 |
| Stage III, n | 156 | 78 | 10,610 | |
| Surgery, n (Col %) | 63 (40.4) | 62 (79.5) | 7,364 (69.4) | <0.001 |
| Surgical Margin positive, n (Col %) | 6 (3.8) | 16 (20.5) | 1,400 (13.2) | <0.001 |
| Chemotherapy, n (Col %) | <0.001 | |||
| Neoadjuvant chemotherapy | 30 (19.2) | 17 (21.8) | 1,843 (17.4) | |
| Adjuvant chemotherapy | 9 (5.8) | 16 (20.5) | 2,077 (19.6) | |
| Radiation therapy, n (Col %) | 0.022 | |||
| Before surgery | 32 (20.5) | 14 (17.9) | 1,697 (16.0) | |
| After surgery | 11 (7.1) | 19 (24.4) | 2,219 (20.9) | |
| Median survival, months | 14.2 | 10.7 | 16.4 | 0.217 |
| Stage IV, n | 325 | 124 | 21,971 | |
| Surgery, n (Col %) | 19 (5.8) | 23 (18.5) | 3,449 (15.7) | <0.001 |
| Surgical margin positive, n (Col %) | 6 (1.8) | 10 (8.1) | 1,203 (5.5) | <0.001 |
| Chemotherapy, n (Col %) | 0.246 | |||
| Neoadjuvant chemotherapy | 7 (2.2) | 2 (1.6) | 423 (1.9) | |
| Adjuvant chemotherapy | 7 (2.2) | 6 (4.8) | 1,332 (6.1) | |
| Radiation therapy, n (Col %) | 0.493 | |||
| Before surgery | 4 (1.2) | 2 (1.6) | 273 (1.2) | |
| After surgery | 4 (1.2) | 1 (0.8) | 719 (3.3) | |
| Median survival, months | 4.5 | 4.0 | 5.7 | 0.019 |
*, only the categories of interest shown in the table for categorical variables; **, the parametric P value is calculated by ANOVA for numerical covariates and Chi-square test for categorical covariates.