Table 1. Mouse characteristics.
| Characteristic | Experiment 1 | Experiment 2 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Blank, N=4 | Control1, N=4 | AB24, N=8 | P | Control2, N=4 | AB48, N=8 | ABWL, N=8 | P | ||
| Body length+, mm | 90.0 (90.0–92.0) | 90.0 (89.5–91.0) | 90 (89.8–90.8) | 0.70 | 92.0 (89.5–93.5) | 92.5 (91.3–93.8) | 91.5 (90.3–93.5) | 0.80 | |
| Baseline weight t=0, gr | 25.1 (24.8–26.4) | 24.8 (24.0–25.4) | 25.4 (24.6–25.8) | 0.69 | 27.4 (27.0–27.8) | 26.4 (25.2–28.4) | 27.0 (25.9–27.8) | 0.72 | |
| Maximal weight loss, % | 4.5 (4.2–4.8) | 3.8 (3.4–4.5) | 5.0 (3.7–7.3) | 0.46 | 4.1 (3.5–4.6) | 15.2 (11.6–17.0)* | 14.2 (12.8–15.5)* | 0.01 | |
+, nose to base of tail; *, P<0.05 compared to Control2 group. AB24, first antibiotics administered at 24 hours after inoculation with S. pneumoniae; AB48, first antibiotics administered at 48 hours after inoculation with S. pneumoniae; ABWL, first antibiotics administered as soon as 10% of body weight was lost after inoculation with S. pneumoniae.