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. 2019 Jan 23;7:4. doi: 10.3389/fbioe.2019.00004

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Copyright © 2019 Rahmati and Mozafari.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) T1-weighted MRIs of tumor-bearing BALB/C mice before (a) and after injecting PC61BA-(Gd-DO3A)/HSA (0.04 mmol Gd3+/kg bw) at 0.5 (b), 1 (c), 4 (d), 8 (e), and 24 h (f) and those of tumor-bearing BALB/C mice before injection (a′) and after injection of Gd-DO3A (0.04 mmol Gd3+/kg bw) at 0.5 (b′), 1 (c′), 4 (d′), 8 (e′), and 24 h (f′). The tumor tissue is painted in the white dotted ring. (B) Changes in the bw of mice which were injected with the agent or saline (C) Evaluation of organ directories of the mice treated with both presented agent and saline as control sample. (D) histologiacl studies of mice injected with the suggested agent (above) and saline (bottom) as control. Adopted from Zhang et al. (2016) with the Elsevier Permission.