Figure 1.

Chd1-mutant mice have normal vision, anxiety, working memory and motivation to explore the environment. (A) Visual ability was tested by the visual cliff test. The number of mice stopping (colored) or not stopping (white) at the cliff is shown for each genotype. No statistically significant difference was detected (Chi-squared test, p > 0.05; n = 13/group). (B) Results of light/dark test for visual ability and anxiety are expressed as time spent in either the light or the dark compartment of the test set-up. Both groups preferred the dark compartment without differences between them (two-way ANOVA; compartment effect: F_(1,48) = 231.8, p < 0.0001; genotype effect: F_(1,48) = 0, p > 0.05; n = 13/group). (C) Working memory and motivation to explore were tested by a spontaneous alternation test using a Y-maze. An alternation was defined as a triplet of sequential location visits. Results are expressed as the fraction of “correct” triplets (sequential visits to three unique locations; left graph) out of all alternations and total number of triplets (right graph). No significant difference was detected for the two genotypes (Mann-Whitney test, p > 0.05 for left graph; p > 0.05 for right graph, n = 8/group). Results were considered significant at p < 0.05 (****p < 0.0001; ns, non-significant). Means ± SEM are shown.