Table 1.
In vitro anti-viral activity against H1N1 A/FM/1/47 by Asprellcosides B and Ilex asprella (Hook. Et Arn.) Champ. Ex Benth isolated from the radix and stems, with different medication modes.
| Virus | Therapy | Asprellcosides B | Oseltamivir | ||
|---|---|---|---|---|---|
| TC50 > 250 μM | TC50 > 250 μM | ||||
| IC50 (μM) | SI (μM) | IC50 (μM) | SI (μM) | ||
| H1N1 | Therapeutic administration | 796.46 | 0.31 | 13.21 | 18.92 |
| Simultaneous administration | 11.21 | 22.30 | 4.26 × 10-5 | 5.87 × 106 | |
| Premixed administration | 18.39 | 13.59 | 1.64 × 10-5 | 1.52 × 107 | |
| Prophylactic administration | 8.87 | 28.18 | 6.10 | 40.98 | |
The TC50 and IC50 values were determined by WST-8 assay and neuraminidase assay. n = 3, each concentration in triplicate.