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. 2019 Jan 23;10:18. doi: 10.3389/fphar.2019.00018

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Copyright © 2019 Vacková, Kopkan, Kikerlová, Husková, Sadowski, Kompanowska-Jezierska, Hammock, Imig, Táborský, Melenovský and Červenka.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Renal tissue concentrations of hydroxyeicosatrienoic acids (HETEs) (A), the renal ratio of epoxyeicosatrienoic acids (EETs) to dihydroxyeicosatrienoic acids (DHETEs) (B), HETE concentrations in the left ventricle (C), and EETs/DHETEs ratio in the left ventricle (D) in the sham-operated FHL rats with ACF and ACF FHL rats treated with the sEH inhibitor, and in sham-operated fawn-hooded hypertensive (FHH) rats, and in untreated or sEH-treated ACF FHH rats. ^∗P < 0.05 compared with the sham-operated counterparts.