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. 2019 Jan 23;9:3038. doi: 10.3389/fimmu.2018.03038

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Copyright © 2019 Chhabra, Alsughayyir, Qureshi, Mallik, Ali, Gamper, Moseley, Peacock, Kosmoliaptsis, Goddard, Linterman, Motallebzadeh and Pettigrew.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Development and characterization of murine model of antibody-mediated heart allograft rejection. (A) Figure is adapted from our companion paper (4). BL/6 Tcrbd^−/− recipients of BALB/c heart allografts were either unmodified (no cells group) or reconstituted the day after with either wild-type or SAP-deficient CD4 T cells from TCR transgenic Rag1^−/− TCR75 animals that recognize I-A^b-restricted H-2K $_{54 - 68}^{d}$ peptide. (B) ELISA assays of serum samples obtained from BL/6 Tcrbd^−/− recipients of BALB/c hearts and reconstituted with 10³ TCR75 CD4 T cells (n = 4) shows progressive increase of anti-H-2K^d IgG alloantibody until day 100.