Fig. 3.

Simulation of the expected pharmacodynamic outcome. a remaining malaria-free after a single treatment regimen, b remaining malaria-free after three rounds of monthly dose regimens (day 0, 30, and 60), and c remaining malaria-free after four rounds of monthly dose regimens (day 0, 30, 60, and 90). Red lines represent the standard WHO 2010 dosing regimen^52,43 and black lines the increased dosing regimens according to the revised WHO 2015 recommendation²⁶ in children (4–20 kg; n = 200 individuals per body weight, 100 replications). Solid lines represent the predicted median survival estimate of the Kaplan–Meier plot and shaded areas represent the 95% prediction intervals. Upward red arrows represent the time of DHA-PQ administrations