Fig. 4.

Comparisons of the expected pharmacodynamic outcomes. a Children (4–20 kg) remaining malaria-free after a single treatment regimen by day 60, b children (4–20 kg) remaining malaria-free after three rounds of a monthly dose regimen by day 120, c children (4–20 kg) remaining malaria-free after three rounds of a monthly dose regimen by day 90, d children (4–20 kg) remaining malaria-free after four rounds of a monthly dose regimen by day 120. Red box-whisker plots represent the standard WHO 2010 dosing regimen^52,43 and blue box-whisker plots represent the increased dosing regimens according to the revised WHO 2015 recommendation²⁶, stratified by body weight. The simulations are based on 200 individuals per body weight for 100 replications. The box-whisker plots represent the median with inter-quartile range and the 95% prediction interval. Right panels represent the proportions of children remaining malaria-free at the end time point; the red filled density plots represent the standard WHO 2010 dosing regimen and the blue filled density plots represent the revised WHO 2015 dosing regimen