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. 2019 Jan 29;10(2):92. doi: 10.1038/s41419-019-1308-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Effects of TTC3 knockdown (a) and TTC3 overexpression (b) on TGF-β signaling. BEAS-2B cells were transfected with TTC3 siRNA (a) and TTC3/DYK plasmids (b) and treated with 10 ng/ml TGF-β₁ for 1 d. c TTC3-mediated proteasomal degradation of SMURF2 in TGF-β₁-treated BEAS-2B cells. After transfection of TTC3 siRNA, BEAS-2B cells were treated with for 10 ng/ml TGF-β₁ for 1 d. MG132 (5 μM) was added 12 h before harvesting the cells