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. 2019 Jan 29;9:837. doi: 10.1038/s41598-018-37139-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Conditional knockout of Tsc1 in the Dermo1 lineage did not result in cystogenesis. (A) Microscopic images of kidney sections of Dermo1-Cre; tdTomato mice showed that Dermo1 could label tubular and glomerulus cells in mouse kidney. (B) Immunofluorescent staining on Dermo1-Cre; tdTomato mouse kidney sections revealed that Dermo1 linage renal cells were negative for the tested markers of different renal cell types. (C) Dermo1-Cre; Tsc1^f/f mouse kidney sections showed increased p-S6 signals. (D) H-E staining (4x) of the kidney sections of 2-month-old Dermo1-Cre; Tsc1^f/f and control mice.