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. 2019 Jan 29;9:884. doi: 10.1038/s41598-018-36696-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Flow cytometry results. (A) Blood flow cytometry results for 40 tuberculous meningitis (TBM) patients showing concentrations of individual cell types as depicted in the legend. (B) Median concentrations in 26 healthy controls, 26 pulmonary tuberculosis and TBM patients for myeloid (left) and lymphoid (right) cell types. (C) CSF flow cytometry results for 41 individual TBM patients. Patients with >200 leukocytes/μL are displayed in the left subplot and patients with ≤200 leukocytes/μL in the right subplot. (D) Median CSF cell composition of all TBM patients combined. Note: CD3⁻ lymphocytes without NK cell markers, most likely B cells (14%, IQR 11–43 of lymphocytes), were not included in the analysis because the flow cytometry panels lacked B-cell markers to formally confirm their phenotype.