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. 2019 Jan 29;9:867. doi: 10.1038/s41598-018-37242-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Alteration of microbial KEGG metabolic pathways in T2DM zebrafish. (A–C) Several KEGG metabolic pathways were downregulated in the microbiome of T2DM zebrafish compared with those of the control group. Arginine and proline metabolism (A), phenylalanine metabolism (B) and butyrate (butanoate) metabolism (C). Red and green indicates downregulation and upregulation, respectively. KEGG pathway maps (ko00330, ko00360, ko00650) are adapted here from http://www.kegg.jp/kegg/kegg1.html. The KEGG database has been described previously⁴⁶.