Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jan 29;9:878. doi: 10.1038/s41598-018-37027-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

SIRT1 protein is reduced in diabetic patients. The concentration of SIRT1 within patient serum was measured by ELISA. (a) SIRT1 serum concentration was significantly decreased by over 75% in diabetic patients (n = 25) compared to healthy controls (n = 25). Representative micrographs of internal mammary artery (IMA) from a non-diabetic patient undergoing CABG surgery, and popliteal artery (PA) harvested from a diabetic patient (DM) undergoing lower limb amputation. (b) Alizarin red staining, positive staining shown by arrow (n = 3). (c) LH panel showing SIRT1 staining (black), lacking in the DM patient (n = 3). Centre panel showing RUNX2 staining (n = 3) and RH panel showing OCN staining (n = 3), positive stain observed in the DM compared to the IMA. **P < 0.005 Scale bar = 200 μm/20 μm.