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. 2019 Jan 29;9:822. doi: 10.1038/s41598-018-35734-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Forest plot of the included studies for outcome oligodendrocyte count. The diamond indicates the global estimate and its 95% confidence interval (CI). The gray bar indicates the 95% CI of the overall effect size. The numbers listed after a certain intervention are: the exact effect size with its 95% CI, the number of included studies for a certain intervention (ns), the total number of treated animals (nt) or control animals (nc). References are given in the Supplementary Information.