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. 2019 Jan 29;9:39. doi: 10.1038/s41398-019-0372-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The 317,349 DNA methylation (DNAm) sites for which data existed after preprocessing and filtering were grouped into 267,249 candidate regions (CRs). Of the 267,249 CRs, 8021 were differentially methylated between age groups, i.e., differentially methylated regions (aDMRs) (FDR < 0.05 and effect size > 3%). Of the 8021 aDMRs, DNAm at 1415 correlated strongly with local gene expression (|Pearson R| ≥ 0.3)