Table 2.
aDMR enrichment of gene sets for aging and psychiatric disease risk in two datasets and meta-analysis
| Gene Sets | Primary dataset | Replication dataset | Meta-analysis |
|---|---|---|---|
| Age | |||
| All aDMRs | OR = 2.30, p = 1.69 × 10−27 | OR = 2.19, p = 9.24 × 10−19 | OR = 2.27, p = 2.52 × 10−23 |
| Hypomethylated aDMRs only | OR = 2.08, p = 3.85 × 10−11 | OR = 1.88, p = 5.55 × 10−7 | OR = 2.28, p = 2.04 × 10−16 |
| Hypermethylated aDMRs only | OR = 2.10, p = 7.21 × 10−18 | OR = 2.21, p = 2.20 × 10−13 | OR = 2.07, p = 2.02 × 10−11 |
| SZ | |||
| SZ risk genes | OR = 2.51, p = 1.50 × 10−4 | OR = 2.01, p = 0.01 | OR = 2.68, p = 0.00012 |
| SZ risk genes (protein-encoding subset) | OR = 5.19, p = 4.7 × 10−7 | OR = 3.88, p = 1.7 × 10−4 | OR = 6.28, p = 3.6 × 10−8 |
| AD | |||
| AD risk genes | OR = 2.38, p = 0.04 | OR = 1.37, p = 0.37 | OR = 2.66, p = 0.0.026 |
| MDD | |||
| MDD risk genes | OR = 3.15, p = 0.05 | OR = 3.32, p = 0.02 | OR = 4.11, p = 0.004 |
| Expression-based MDD-associated genes | OR = 1.48, p = 1.2 × 10−4 | OR = 2.01, p = 1.3 × 10−9 | OR = 1.83, p = 2.1 × 10−8 |
DMRs differentially methylated regions, OR odds ratio, SZ schizophrenia, AD Alzheimer’s disease, MDD major depressive disorder
Values in bold italics are statistically significant (p < 0.05)