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. 2019 Jan 29;9:921. doi: 10.1038/s41598-018-37528-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In-vitro anti-inflammatory effect of ADMPC. Expression of immunosuppressive and pro-inflammatory-related cytokines by ADMPC treated with cytokine cocktail. Significant up-regulation of the (a) immunosuppressive cytokines GBP4, IL1RA, CXCL10, and IDO and down-regulation of the (b) pro-inflammatory cytokines IL6, IL17, and TNFα by ADMPC cultured with cytokine cocktail compared with the absence of cytokine treatment. (c) GBP4 and IL1RA gene expression of ADMPC compared with gingival fibroblasts. Data are expressed as the mean ± S.D. *p < 0.05 compared with the control.