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. 2019 Jan 29;9:921. doi: 10.1038/s41598-018-37528-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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µCT analysis of new bone regeneration by allogeneic ADMPC. (a) Three-dimensional reconstruction of µCT images of the furcation defect is shown. The yellow area highlighted by the arrowhead represents new bone formation within the defect area under 3D view. Furcation defect area viewed in the coronal, axial and sagittal views; the persistence of radiolucency (arrowhead) observed in the defect area in the control sample (upper panel) compared with increased radiopacity (arrowhead) in the defect area of allogeneic (middle panel) and autologous (lower panel) ADMPC transplants. Quantification of regenerated alveolar bone from reconstructed three-dimensional µCT images showing that the amount of newly formed bone was significantly higher in (b) allogeneic and (c) autologous ADMPC transplants compared with the control group. (Data are expressed as the mean ± S.D). *p < 0.05 compared with the control.