Table 2.
Haplotype structure of five coding sequence variants in the SLC16A11 gene and their estimated frequencies.
| SNP | Inferred haplotypes | chr17: position | Amino Acid | LD group* | Type | ||
|---|---|---|---|---|---|---|---|
| Reference | 2-SNP | 5-SNP | |||||
| rs75493593 | G | G | T | 6945087 | P443T | 2 | Imputed (r2 = 99.9) |
| rs75418188 | C | C | T | 6945483 | G340S | 2 | Imputed (r2 = 99.9) |
| rs13342232 | A | G | G | 6945940 | L187L | 1 | genotyped |
| rs13342692 | T | C | C | 6946287 | D127G | 1 | genotyped |
| rs117767867 | C | C | T | 6946330 | V113I | 2 | Imputed (r2 = 99.8) |
*LD group: linkage disequilibrium between SNP pairs within each of the two groups in HCHS/SOL is r2 > 0.99, while r2 values for SNP pairs between groups varies among groups (0.75 for Central American, 0.89 for Mexican, 0.85 for South American, 0.37 for Cuban, 0.11 for Dominican and 0.33 for South American groups).