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. 2019 Jan 29;9:872. doi: 10.1038/s41598-018-37318-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PNI up-regulates Mincle mRNA at the transection site. (a–c) Dark field and bright field images of the same area of ISHH revealed mRNA distribution of Mincle mRNA after PNI in the L4 DRG and SN, 12 h after PNI, contralateral (a), ipsilateral (b), and 3 days after PNI, ipsilateral site (c). Arrowheads indicate positive cells. Scale bar: Dark field and bright field images, 400 μm, transection site, 80 μm. Counterstained with haematoxylin. (d,e) Bright-field photomicrographs of combined ISHH for Mincle mRNA with immunostaining with Ly6G or F4/80 in the ipsilateral SN. Arrowheads indicate cells single-labelled with ISHH (aggregation of grains). Arrows indicate cells double-labelled with ISHH (aggregation of grains) and IHC (brown staining). Counterstained with haematoxylin. Scale bar: 20 μm.