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. 2019 Jan 29;9:853. doi: 10.1038/s41598-018-36600-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Increased and decreased sulfur compounds in hypoxia. (A,B) Relative quantification of increased (A) and decreased (B) sulfur-containing compounds in the cells in aerobic conditions and hypoxia. Procedure defined unit is calculated by normalizing the LC/MS signals to that of aerobic condition for each compound. Error bars indicate SD. N.D. indicates that the compound is not detected in the condition. n = 3, *p < 0.05 t-test, **p < 0.05 t-test with Bonferroni’s correction, ^†compounds are not detected in either of the conditions. (C) An illustration of the metabolic network of sulfur compounds. The arrows between compounds indicate metabolic reactions. The superscript for each compound indicates the upregulation (UP) or downregulation (DOWN) of the compound with or without a mark indicating the significant difference (*p < 0.05 t-test, **p < 0.05 t-test with Bonferroni’s correction, ^†compounds are not detected in either of condition). (D) Quantification of protein in the cells in aerobic conditions and hypoxia. Error bars indicate SD. n = 3, *p < 0.05 t-test.