Table 1.

Inhibitory activity of benzofuran derivatives in LPS-induced inflammation^a.

Code No.	Structure		at 40 µM		IL-6 inhibition (IC50, µM)
	R1	R2	NO inhibition (%)	Viability (%)
8			13.26 ± 0.84	43.69 ± 0.49	19.94 ± 1.26
10	—		16.59 ± 3.83	56.55 ± 3.50	N.D.
12			23.08 ± 5.97	76.92 ± 4.85	48.69 ± 4.55
13			33.84 ± 1.83	62.34 ± 1.60	28.30 ± 0.07
14			33.53 ± 2.50	95.45 ± 15.18	35.61 ± 0.12
15			30.22 ± 0.27	7.21 ± 0.01	>40
17a			−3.40 ± 6.03	36.19 ± 2.20	>40
17b			−1.05 ± 0.17	25.71 ± 0.69	>40
22a			12.94 ± 2.29	95.28 ± 2.25	15.89 ± 0.06
22b			41.88 ± 2.67	92.76 ± 8.04	>40
22c			24.58 ± 2.96	105.93 ± 0.55	>40
22d			17.99 ± 0.65	103.31 ± 3.41	20.31 ± 0.01
22e			12.86 ± 3.53	94.80 ± 1.20	>40
22 f (DK-1014)			30.36 ± 9.82	101.30 ± 1.48	16.19 ± 0.20
22 g			93.32 ± 1.88	8.34 ± 3.42	8.34 ± 3.42
22 h			68.52 ± 2.14	8.44 ± 1.44	>40
22i			78.37 ± 1.01	8.48 ± 0.69	>40
22j			18.91 ± 6.94	98.93 ± 14.41	>40
22k			25.25 ± 8.16	95.99 ± 6.08	>40
22 l			86.23 ± 0.45	0.49 ± 0.02	24.19 ± 6.48
22 m			21.92 ± 2.35	114.97 ± 1.09	>40
22n			36.51 ± 5.44	55.62 ± 2.36	>40
22o			17.58 ± 0.50	77.04 ± 12.72	>40
22p			53.83 ± 2.70	5.21 ± 3.61	>40
22q			90.12 ± 2.03	10.82 ± 5.2	>40

^aValues are the mean of three experiments.

N.D., not determined.