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. 2019 Jan 29;9:868. doi: 10.1038/s41598-018-37340-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Deregulation of JMJD3 and its underlying mechanism by bioinformatics study. (A) The two transcript variants of JMJD3 were both upregulated in GC as analyzed by The Human Protein Atlas. (B) Patients with hypermutation had significantly lower level of JMJD3 expression as analyzed by cBioportal using TCGA data. (C) Patients with MLH1 silencing had significantly lower level of JMJD3 expression as analyzed by cBioportal using TCGA data. (D) Deletion, diploid, copy number gain and amplification were involved in the deregulation of JMJD3 expression as analyzed by cBioportal using TCGA data. (E) DNA methylation was also involved in JMJD3 deregulation stage as analyzed by cBioportal using TCGA data.*p < 0.05.