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. 2019 Jan 29;9:868. doi: 10.1038/s41598-018-37340-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The downstream targets of JMJD3 by bioinformatics study. (A) Genes that were positively co-expressed with JMJD3 and at the same time negatively co-expressed with EZH2 were analyzed by Venny using TCGA data. (B) Genes that were significantly influenced by JMJD3 expression alteration were analyzed by cBioportal. (C) Net work analysis was performed in cBioportal and four direct and five indirect targets of JMJD3 were found.