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. 2019 Jan 29;9:857. doi: 10.1038/s41598-018-37408-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo iron MRI (FeMRI) of murine macrophage iron deposits and correlation between immune and therapeutic CSF1R inhibitor response. Representative in vivo FeMRI axial cross sections of the mammary tumors are shown in control and BLZ945 treated (a,b) TS1, and (c,d) 99LN models. Scale bar 2.5 mm. Expansions show high-iron pixel clusters. Scale bar 200 µm. (e) Number (#) of high-iron FeMRI pixel clusters in the TS1 and 99LN tumors in the CSF1R inhibitor trials (mean + s.e.m. n = 8 mice/group, **p < 0.01 two-tailed unpaired students t-test). Linear correlations between high-iron FeMRI clusters and tumor volumes in the control(ο) and BLZ945-treated(•) (f) TS1 and (g) 99LN MMTV-PyMT tumor models (n = 8 mice/group, R² and correlation p-value from linear Pearson correlation are shown).