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. 2019 Jan 29;9:900. doi: 10.1038/s41598-018-36954-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Administration method effect on particle-cell interaction is heavily dependent on particle material, size, and surface coating. Cellular uptake by J774A.1 murine cells and UV-Vis analysis of (a–c) PVA-coated AuNPs and (d–f) PEG-coated AuNPs. J774A.1 uptake of (g) PVP-coated SiO₂ NPs and (h) PVP-coated superparamagnetic iron oxide NPs. (b,e) LSPR band shift for PVA-coated and PEG-coated AuNPs, respectively, following the concentrated or pre-mixed administration. (c,f) Time-dependent change of the extinction intensity (Δext) with respect to the extinction in water at maximum for PVA-coated and PEG-coated AuNP, respectively. Lines indicate modified ISDD fit of data with concentrated or pre-mixed assumptions. Inset TEM micrographs show (g) PVP-coated SiO₂ and (h) PVP-coated superparamagnetic iron oxide NPs. Scale bars represent 500 nm.