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. 2019 Jan 29;9:913. doi: 10.1038/s41598-018-37485-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Identification of a renal-lineage master regulatory TF. (a) Diagram of differentiation into mature kidney. (b) Flowchart of an approach to identify renal linage master regulatory TFs. (c) Schematic representation of time course of mRNA transfection of candidate TFs. (d) Relative mRNA expression levels of CDH16 after mRNA transfection of candidate TFs into hESCs. (e) Representative bright-field images on day 5 of differentiation. Scale bar, 100 μm. (f) Time course of gene expression of AQP1, CDH16, PAX2, and LRP2 in transgene HNF1A-induced hESCs (white bars), in transgene un-induced hESCs, and in RPTECs (black bars) by qRT-PCR from day 0 to 8 n = 2. Data represent mean + s.e.m. P-values were determined by a Student’s t-test. *P < 0.05; **P < 0.01.