TABLE 2.
Key gut microbiota composition and metabolites responsible for distinguishing among children with ASD and children with typical development
| Marker names | Marker type | Description | FDR value (Deseq2) |
Regulation mode |
|---|---|---|---|---|
| d-Glutamine and d-glutamate metabolism | Gut microbiota pathways | Glutamate metabolism | 5.5893E-05 | Down |
| 2-Keto-glutaramic acid | Gut metabolites | Glutamate metabolism | 0.009440927 | Down |
| l-Aspartic acid | Gut metabolites | Glutamate metabolism | 0.015566567 | Down |
| Bacteroides vulgatus | Gut microbiota taxons | Glutamate-fermenting commensal | 0.005836312 | Down |
| Benzoate degradation | Gut microbiota pathways | Aromatic compound metabolism | 0.012717845 | Up |
| Naphthalene degradation | Gut microbiota pathways | Aromatic compound metabolism | 0.025979256 | Up |
| Tyrosine metabolism | Gut microbiota pathways | Aromatic compound metabolism | 0.011855325 | Up |
| Benzaldehyde | Gut metabolites | Aromatic compound metabolism | 0.00746784 | Down |
| l-Phenylalanine | Gut metabolites | Aromatic compound metabolism | 0.014748155 | Down |
| l-Tyrosine | Gut metabolites | Aromatic compound metabolism | 0.004732451 | Down |
| Chenodeoxycholic acid 3-sulfate | Gut metabolites | Gut bile acid metabolism | 0.046136738 | Up |
| Taurocholic acid | Gut metabolites | Gut bile acid metabolism | 0.028487916 | Up |
| Epinephrine | Gut metabolites | Gut hormone | 0.019309289 | Down |
| 11-Deoxy PGF2 | Gut metabolites | Gut hormone | 1.36591E-10 | Down |
| Cortisol | Gut metabolites | Gut hormone | 1.99163E-07 | Down |
| Eggerthella lenta | Gut microbiota taxons | Bile acid metabolism taxons | 0.013429179 | Up |
| Clostridium botulinum A3 strain Loch Maree | Gut microbiota taxons | Bile acid metabolism taxons | 0.021268458 | Up |
| Clostridium botulinum Ba4 strain 657 | Gut microbiota taxons | Bile acid metabolism taxons | 0.033169563 | Up |
| Eggerthella lenta DSM 2243 | Gut microbiota taxons | Bile acid metabolism taxons | 0.010687164 | Up |