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. 2018 Dec 28;17(2):2356–2364. doi: 10.3892/ol.2018.9880

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Knockdown of SNHG12 suppresses proliferation and induces apoptosis in non-small cell lung cancer cells. (A) Reverse transcription-polymerase chain reaction analysis of the expression level of SNHG12 in A549 and H1299 cells following treatment with SNHG12-inhi. Viability of (B) A549 and (C) H1299 cells was determined using an MTT assay following treatment with SNHG12-inhi. Proliferation of (D) A549 and (E) H1299 cells was assessed using a colony formation assay. (F) Apoptosis of A549 and H1299 cells induced by SNHG12 was detected using Annexin V/propidium iodide staining and flow cytometry. (G) The expression levels of caspase-associated proteins were analyzed by western blot analysis. **P<0.01, ***P<0.001. SNHG12, small nucleolar RNA host gene 12; inhi, inhibitor; NC, negative control.