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. 2018 Dec 28;17(2):2356–2364. doi: 10.3892/ol.2018.9880

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — SNHG12 interacts directly with miR-218 and acts as a sponge. (A) Predicted binding sites between SNHG12 and miR-218. Expression levels of miR-218 in (B) A549 and (C) H1299 cells following treatment with SNHG12-inhi. ***P<0.001 vs. NC-inhi. (D) Luciferase activity in A549 cells co-transfected with miR-218-mimic or miR-NC or pmiR-RB-REPORT™-SNHG12-WT or pmiR-RB-REPORT™-SNHG12-MUT. ***P<0.001 vs. SNHG12-wt. SNHG12, small nucleolar RNA host gene 12; inhi, inhibitor; NC, negative control; wt, wild-type; miR, microRNA; mut, mutant.