Table 1.
Selected enriched gene sets obtained with Reactome analysis that included terms related to axon-related proteins, synapses, and potassium channels
| Category | Gene | Expression |
|---|---|---|
| Axon-related protein | NEFH | Up |
| STMN2 | Down | |
| PLP1 | Down | |
| NCAN | Down | |
| RGMA | Down | |
| UNC5A | Down | |
| Synapsis | NRXN1 | Down |
| NRXN2 | Down | |
| NRXN3 | Down | |
| SYT7 | Up | |
| SYT9 | Down | |
| SYT11 | Up | |
| SYT13 | Down | |
| VAMP8 | Down | |
| SYCP2 | Down | |
| RIMS4 | Down | |
| BSN | Down | |
| SNAP91 | Down | |
| STXBP1 | Up | |
| Potassium channels | KCNA3 | Down |
| KCNA5 | Down | |
| KCNC1 | Down | |
| KCND2 | Down | |
| KCNF1 | Down | |
| KCNG1 | Down | |
| KCNJ10 | Down | |
| KCNK3 | Down | |
| KCNN1 | Down | |
| KCNN2 | Down | |
| KCNQ3 | Up | |
| KCNC4 | Up | |
| KCNN4 | Up |
The selected genes upregulated and downregulated in SMA motor neurons are shown in bold and italics, respectively.