Figure 1.

Survival of implanted homozygous Cacna1a^S218L mice and fatal seizure duration in implanted and naïve mice. (A) Survival plot of 26 implanted homozygous Cacna1a^S218L mice showing that the majority of mice died within 1 week after surgery. Note that during recovery from surgery (shaded grey), approximately half of the mice (n = 12) died. In the remaining mice (n = 14), which were monitored in the ECoG set-up for 2 weeks, fatal seizures occurred in all, except one that survived the recording period. Note, one additional mouse died following status epilepticus and was excluded from further analysis and not included in the plot. (B) Duration of spontaneous fatal seizure behaviour was not different for naïve and implanted mice (P = 0.50; data shown as mean ± SD).