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. 2019 Jan 12;142(2):412–425. doi: 10.1093/brain/awy325

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Brainstem DC recordings during a spontaneous fatal seizure in a homozygous Cacna1a^S218L mouse. Example of a spreading depolarization (indicated by arrowheads) that occurred during seizure behaviour in the oral pontine reticular nucleus (PnO) and subsequently in the medullary reticular formation (MRF), followed by visual cortex (V1) AC ECoG suppression, bradycardia and cortical terminal depolarization (TD; indicated by an arrow). Note that ictal V1 AC ECoG amplitude was greatly reduced following cortical spreading depolarization. AC = alternating current; bps = beats per second; DC = direct current; IHR = instantaneous heart rate.