Figure 4.

Hyperactivity of cortical neurons expressing the Scn8a^R1872W mutant sodium channel. (A and B) Representative slice recordings from control (14 cells from four mice) and Scn8a^cond/+,EIIa-Cre CA1 neurons (16 cells from five mice). (C) Action potential firing frequency at 400 pA current injection. (D and E) Representative slice recordings from control (12 cells from four mice) and Scn8a^cond/+,EIIa-Cre layer V cortical neurons (16 cells from five mice). (F) Action potential firing frequency at 400 pA current injection. Data shown represent means ± standard error of the mean (SEM) *P < 0.05, ***P < 0.001.