Figure 3.

Differential cell‐free DNA (cfDNA) signals reveal a loss of signals in compartment A1 and B1 and a gain of signals in compartment B2 and B3 with age. (a) Log fold change of cfDNA signals with 100 kb spanning across chr 11 of each age group relative to young. Colors represent the compartment that these 100‐kb spanning regions are in based on GM12878 Hi‐C data. (b) The distribution of log fold change of cfDNA signals by compartments in chr 11. (c) The distribution of log fold change of cfDNA signals by compartments in all chromosomes. (d) The 3D organization of chr 11 at 100 kb resolution, colored by the log fold change of cfDNA signals