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Local nucleosome profiles’ changes with age. (a) Average cell‐free DNA signals at transcription start sites, (b) transcription termination sites, and (c) CCCTC‐binding factor (CTCF) showed an expected NDR flanked by well‐positioned nucleosomes, but these signals attenuate with age. CTCF has been shown to play roles in mediating the formation of chromatin loops
