Table 1.

Change of cell‐free DNA signals across different age groups. The change in direction is only identified for significant comparisons in which zero is excluded from the credible interval

	Comparisons	Mean of fold change	Difference in posterior median	Credible interval	Change in direction	p‐Value
A1	Healthy centenarian–old	0.0448	0.0282	0.0268, 0.0298	Increased signal	<0.0001
	Healthy centenarian–unhealthy centenarian	0.0760	0.0478	0.0461, 0.0494	Increased signal	<0.0001
	Healthy centenarian–young	−0.0871	−0.0472	−0.0487, −0.0455	Decreased signal	<0.0001
	Old–unhealthy centenarian	0.0312	0.0196	0.018, 0.0212	Increased signal	<0.0001
	Old–young	−0.1319	−0.0754	−0.0769, −0.0738	Decreased signal	<0.0001
	Unhealthy centenarian–young	−0.1631	−0.095	−0.0967, −0.0933	Decreased signal	<0.0001
A2	Healthy centenarian–old	0.0177	0.009	0.0082, 0.01	Increased signal	<0.0001
	Healthy centenarian–unhealthy centenarian	0.0130	0.0045	0.0037, 0.0054	Increased signal	<0.0001
	Healthy centenarian–young	−0.0166	−0.0006	−0.0015, 0.0003	—	0.5613
	Old–unhealthy centenarian	−0.0047	−0.0045	−0.0054, 0.0036	Decreased signal	<0.0001
	Old–young	−0.0343	−0.0096	−0.0104, −0.0086	Decreased signal	<0.0001
	Unhealthy centenarian–young	−0.0297	−0.0051	−0.006, −0.0041	Decreased signal	<0.0001
B1	Healthy centenarian–old	−0.0004	−0.0034	−0.0049, −0.0018	Decreased signal	<0.0001
	Healthy centenarian–unhealthy centenarian	0.0338	0.0185	0.0171, 0.02	Increased signal	<0.0001
	Healthy centenarian–young	−0.0591	−0.0288	−0.0303, −0.0274	Decreased signal	<0.0001
	Old–unhealthy centenarian	0.0342	0.0218	0.0204, 0.0233	Increased signal	<0.0001
	Old–young	−0.0587	−0.0255	−0.027, −0.0241	Decreased signal	<0.0001
	Unhealthy centenarian–young	−0.0928	−0.0474	−0.0487, −0.0459	Decreased signal	<0.0001
B2	Healthy centenarian–old	−0.0118	−0.0112	−0.0125, −0.0099	Decreased signal	<0.0001
	Healthy centenarian–unhealthy centenarian	−0.0181	−0.0169	−0.0183, −0.0156	Decreased signal	<0.0001
	Healthy centenarian–young	0.0086	0.0169	0.0156, 0.0183	Increased signal	<0.0001
	Old–unhealthy centenarian	−0.0063	−0.0057	−0.0071, −0.0044	Decreased signal	<0.0001
	Old–young	0.0204	0.0281	0.0268, 0.0296	Increased signal	<0.0001
	Unhealthy centenarian–young	0.0267	0.0338	0.0326, 0.0351	Increased signal	<0.0001
B3	Healthy centenarian–old	−0.0163	−0.0143	−0.015, −0.0135	Decreased signal	<0.0001
	Healthy centenarian–unhealthy centenarian	−0.0326	−0.027	−0.0278, −0.0262	Decreased signal	<0.0001
	Healthy centenarian–young	0.0376	0.037	0.0363, 0.0379	Increased signal	<0.0001
	Old–unhealthy centenarian	−0.0163	−0.0128	−0.0135, −0.012	Decreased signal	<0.0001
	Old–young	0.0539	0.0513	0.0505, 0.0520	Increased signal	<0.0001
	Unhealthy centenarian–young	0.0702	0.0641	0.0632, 0.0648	Increased signal	<0.0001