Figure 2.

Accumulation patterns of damage types and senescent cells in an organism subjected to lifespan‐modifying interventions. (left graph) Repairable damage, such as oxidative damage, exhibits a full reversal of the phenotype so that an intervention extending the lifespan sharply decreases damage level, while an intervention decreasing lifespan elevates damage. (middle graph) Level of irreparable damage, such as lipofuscin, is not changed by lifespan‐modulating interventions, in contrast to the rate of its accumulation, demonstrating the importance of life history on irreparable damage accumulation. (right graph) Markers of cell senescence change independently of damage markers. Upon entering a lifespan‐extending treatment, an organism shows a long‐lasting decrease in senescence markers. Changing the conditions to lifespan shortening does not affect the current status of senescence markers but might impact on the rate of senescent cell accumulation