Figure 2.
dilp1 mutation suppresses aging and Akh phenotypes of mutant dilp2. (a) dilp2 mutants but not double mutants are long‐lived, Cox hazard analysis p < 0.0001, χ 2 = 201, n = 341–365 per genotype. (b) dilp2 mutants but not double mutants have decreased mortality. (c) dilp2 mutants but not double mutants have increased Akh mRNA expression, female adults at 7‐ to 10‐day‐old, n = 9 per genotype. Two‐way ANOVA dilp1 p ≤ 0.001, dilp2 p = 0.921, dilp1 × dilp2 interaction p < 0.001. (D) dilp2 mutants but not dilp1 or double mutants have increased AKH immune‐labeling in corpora cardiaca from 6‐ to 7‐day‐old female flies, representative images. (E) Quantification of AKH immune‐labeling, n = 9–14 samples from three replicates, ANOVA *p < 0.05