Table 2.
Comparison of characteristics between preadmission statin user and non-statin user.
| Variables | Statin Group n = 5756 |
Non-Statin Group n = 15,480 |
p-Value | |
|---|---|---|---|---|
| Sex: male | 3398 (59.0%) | 9036 (58.4%) | 0.384 | |
| Age, year | 68.6 (12.0) | 62.2 (16.6) | <0.001 | |
| Body Mass Index, kg m−2 | 24.6 (3.8) | 23.3 (3.8) | <0.001 | |
| Comorbidities at ICU admission | ||||
| APACHE II | 19.8 (9.8) | 20.2 (10.1) | 0.012 | |
| eGFR a | <0.001 | |||
| ≥90 | 3073 (53.4%) | 9920 (64.1%) | ||
| 60–90 | 1488 (25.9%) | 3039 (19.6%) | ||
| 30–60 | 764 (13.3%) | 1.600 (10.3%) | ||
| <30 | 431 (7.5%) | 921 (5.9%) | ||
| Hypertension | 3672 (63.8%) | 5674 (36.7%) | <0.001 | |
| Diabetes mellitus | 830 (14.4%) | 1139 (7.4%) | <0.001 | |
| Ischemic heart disease | 314 (5.5%) | 224 (1.4%) | <0.001 | |
| Cerebrovascular disease | 505 (8.8%) | 440 (2.8%) | <0.001 | |
| Chronic obstructive lung disease | 229 (4.0%) | 692 (4.5%) | 0118 | |
| Liver disease (LC, hepatitis, fatty liver) | 87 (1.5%) | 596 (3.9%) | <0.001 | |
| Anemia (Hb < 10 g dL−1) | 1774 (30.8%) | 5795 (37.4%) | <0.001 | |
| Cancer | 875 (15.22%) | 3433 (22.2%) | <0.001 | |
| Admission through ED | 2640 (45.9%) | 9402 (60.7%) | <0.001 | |
| Admission department | <0.001 | |||
| Internal medicine | 1317 (22.9%) | 3354 (21.7%) | ||
| Neurologic center | 1252 (21.8%) | 3723 (24.1%) | ||
| Cardiothoracic surgical department | 2166 (37.6%) | 4709 (30.4%) | ||
| Other surgical department | 1021 (17.7%) | 3694 (23.9%) | ||
| Total serum cholesterol at ICU adm, mg dL−1 | 125.2 (37.6) | 143.1 (50.4) | <0.001 | |
| Length of hospital stay, day | 11.3 (22.5) | 13.5 (19.0) | <0.001 | |
| Length of ICU stay, day | 2.5 (15.3) | 3.3 (7.2) | <0.001 | |
| Total acute kidney injury | 1301 (22.6%) | 4168 (26.9%) | <0.001 | |
| Acute kidney injury stage ≥2 | 439 (7.6%) | 1777 (11.5%) | <0.001 | |
| RRT after ICU adm within 72 h | 140 (2.4%) | 348 (2.2%) | 0.426 | |
Presented as number (percentage) or mean value (standard deviation). Two sample t-test for continuous variables and chi-square test for categorical variables were used: a: eGFR (mL min −1 1.73 m−2): 186 × (Creatinine)−1.154 × (Age)−0.203 × (0.742 if female); ICU, intensive care unit; APACHE, acute physiology and chronic health evaluation; eGFR, estimated glomerular filtration rate; LC, liver cirrhosis; Hb, hemoglobin; ED, emergency department; RRT, renal replacement therapy.