Variables			Odds Ratio (95% CI)	p-Value
Sex: male			1.06 (1.00–1.13)	0.066
Age, year			1.02 (1.02–1.02)	<0.001
Body mass index, kg m−2			0.96 (0.95–0.97)	<0.001
APACHE II			1.04 (1.04–1.04)	<0.001
Comorbidities at ICU admission
	Hypertension		1.26 (1.18–1.34)	<0.001
	Diabetes mellitus		1.46 (1.32–1.61)	<0.001
	Ischemic heart disease		1.17 (0.97–1.42)	0.101
	Cerebrovascular disease		1.31 (1.14–1.51)	<0.001
	Chronic obstructive lung disease		1.13 (0.97–1.31)	0.109
	Liver disease (LC, hepatitis, fatty liver)		2.48 (2.13–2.89)	<0.001
	Anemia (Hb < 10 g dL−1)		3.82 (3.58–4.07)	<0.001
	Cancer		1.90 (1.77–2.05)	<0.001
	eGFR mL min−1 1.73 m−2
		≥90	1	<0.001
		60–90	0.99 (0.91–1.07)	0.731
		30–60	2.08 (1.89–2.28)	<0.001
		<30	5.18 (4.61–5.82)	<0.001
Admission through emergency department			1.52 (1.43–1.62)	<0.001
Total serum cholesterol at ICU adm
160–200 mg dL−1			1	<0.001
<160, mg dL−1			2.21 (2.01, 2.43)	<0.001
>200 mg dL−1			0.81 (0.69, 0.94)	<0.001
Admission department
	Internal medicine		1	<0.001
	Neurologic center		0.25 (0.23–0.28)	<0.001
	Cardiothoracic surgical department		0.78 (0.72–0.84)	<0.001
	Other surgical department		0.83 (0.76–0.90)	<0.001
Year at ICU admission
	2012		1	<0.001
	2013		1.31 (1.16–1.48)	<0.001
	2014		1.26 (1.12–1.42)	<0.001
	2015		1.09 (0.97–1.23)	0.150
	2016		1.02 (0.91–1.15)	0.690
	2017		0.96 (0.86–1.08)	0.535

All covariates of p < 0.1 in univariable logistic regression analysis were included in multivariable logistic regression analysis; ICU, intensive care unit; AKI, acute kidney injury; APACHE, acute physiology and chronic health evaluation; LC, liver cirrhosis; Hb, hemoglobin.